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Mechanistically, FSP1 exerts its effects through the quinone oxidoreductase activity associated with NADH, converting ubiquinone to ubiquinol, which in turn inhibits lipid peroxidation and ferroptosis (80)

Gastrointestinal Healing: Assessment of its efficacy in accelerating ulcer and leaky gut syndrome recovery in animal models and small human trials
doi: 10.1038/sj.onc.1204064

For endometriosis patients who experience pain far out of proportion to visible disease, or who continue experiencing pain even after surgical excision of lesions, this central mechanism could explain why some report meaningful improvement on GLP-1 medications

Delachat, A
However, their activation by GST involves the production of an intermediate GSH-conjugate