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Another strategy to improve sensitivity to leptin is to inhibit the autoinhibitory factors involved in leptin signaling, i.e., suppressor of cytokine signaling-3 and PTP1B

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These include low bioavailability, poor pharmacokinetics, and rapid clearance by the kidneys

There could be many reasons for the retarded growth of plants under LT stress like ROS production, improper nutrient uptake and osmotic imbalance 27

Biol 10 (8) (2003) 677693