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Some relevant physiological evidence comes from analysis of catalase-deficient plants which, as noted above, are useful systems for probing the potential functions of reductive H 2 O 2 -metabolizing pathways in vivo (Dat et al., 2001

& Tackett, A

(2009) Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs

Conclusions from research studies published to date are limited due to small sample sizes, lack of randomization in some studies, and a need for more precise tests of thiamin nutritional status

It also discusses its limitations, emphasizing the need for further longitudinal and interventional studies to confirm whether modulating homocysteine levels could be a viable therapeutic strategy for MASLD