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Chronic hepatitis C in children: the pathological and clinical spectrum

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Bleeding or crusting : Bleeding, scabbing, crusting, or an open sore can be concerning, especially if it heals and then keeps coming back

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Within the technique of immunohistochemistry, special mention must be made of preferentially expressed antigen in melanoma antibody (PRAME), whose expression in the nucleus should give cause for concern in the case of a histologically atypical melanocytic lesion.74,75 Staining with PRAME should not be evaluated in absolute terms (positive/negative), but rather in relative terms (intensity and percentage of staining)