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2 , 5 , 8 , 9 , 10 Classically, in the presence of T3, conformational changes in the ligand-binding domain lead to the recruitment of coactivators, including CREB binding protein (CBP)/p300 and steroid receptor coactivator 1 (SRC1), promoting gene transcription (Figure 1)
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On the outer mitochondrial membrane, CPTI (carnitine-palmitoyl transferase I) catalyzes the transfer of medium/long-chain fatty acids esterified to coenzyme A (CoA) to L-carnitine
