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1 A liver biopsy specimen showing a single portal epithelioid granuloma (arrow) surrounded by a thin cuff of lymphocytes H&E, 100

The dataset was then imported into R software [R version 3.4.2] and normalized using log transformation for multivariate analysis, unsupervised principle component analysis (PCA), and partial least squares-discriminant analysis (PLS-DA)

Ando, H

This was warranted because only three samples per treatment were used in the initial RNA-Seq experiment, which may have affected overall false-positive rates and statistical power

This approach, which embeds mechanistic toxicology as an a priori design tool, is presented as the critical pathway to rationally decouple efficacy from hazard

for acute deficiency, treatment may continue until clinical signs resolve and laboratory values normalize