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This shift parallels the Warburg effect observed in many cancers

Distribution MTX can be distributed to synovial fluid in amounts similar to those in plasma (Herman et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 103.Jacob L, de Brito Neto J, Lenck S, Corcy C, Benbelkacem F, Geraldo LH, Xu Y, Thomas J-M, El Kamouh M-R, Spajer M, Potier M-C, Haik S, Kalamarides M, Stankoff B, Lehericy S, Eichmann A, Thomas J-L

The significant increase in SOD activity associated with the decrease in plasma ceruloplasmin, antioxidant vitamins and the whole blood GPX activity in protein energy malnourished children suggest that these children are potentially susceptible to high oxidative stress

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Lee S (Medical Information, Chiesi, Cary, NC ): Personal communication