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If T3 and T4 levels are high, less TSH is secreted, and the reverse occurs when the T3 and T4 levels are too low, when more TSH is secreted
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It attaches to environmental toxins like pesticides, toxic metals and alcohol making them more water soluble and therefore able to be excreted

Desensitization: receptor becomes less responsive when exposed to a high concentration of an agonist drug
