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Beyond cell models, utilizing an organ-on-a-chip model, which is a microfluidic cell culture device that replicates the structure and function of a specific human organ or tissue, may allow researchers to study organ-level responses to drugs, phytonutrients, or synergistic combinations of nutrients in a controlled environment (111113)

It has been used in the treatment of numerous conditions since antiquity, not only to relieve symptoms of migraine but also to alleviate pain of another origin, inflammation, nausea, and vomiting [97]

In 2009, alcohol abuse claimed 2.3 million lives internationally (Mokdad et al., 2004)

Henceforth, the expression of stable yet divergent gene regulatory networks can be assigned to specify locations without being negated due to the dilution effect of direct unsupervised analysis

Chassaing et al