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In Phase I metabolism, paracetamol is primarily metabolized by the enzyme CYP2E1, resulting in the formation of a toxic metabolite called N-acetyl-p-benzoquinonimine (NAPQI)

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Therefore, although studies investigating the association between matcha tea and cardio-metabolic outcomes show promising results, more clinical studies on humans are needed to confirm these associations

For instance, pegylated FGF-21 analogs have demonstrated promising results in treating NAFLD [279], while recombinant FGF-21 (rFGF-21) has demonstrated the ability to ameliorate BBB damage caused by T2DM [286]