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Description
Truncation studies showed that the membrane proximal 61 amino acids of GP130 are sufficient for signal transduction (68), and later it was shown for GHR that the membrane proximal 20 residues (which includes the Box1 motif) of the ICD is sufficient for JAK2 binding, but not sufficient for GH-induced activation of JAK2 (69)
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J Trauma 47:904910 Delaughter MC, Taffet GE, Fiorotto ML et al (1999) Local insulin-like growth factor I expression induces physiologic, then pathologic, cardiac hypertrophy in transgenic mice

Steiger A and Holsboer F (1997)

This rapid transit minimizes temperature exposure during shipping compared to international orders that may spend weeks in various conditions

It works on a different receptor system the amylin receptor meaning it addresses appetite and weight through a biological pathway that GLP-1 medications do not directly target
