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A significant difference in patient behavior, based upon the average of investigator ratings on the SKAMP-DS across the 8 assessments were observed between patients when they received VYVANSE compared to patients when they received placebo (Study 2 in Table 6)

[DOI] [PubMed] [Google Scholar] 150.Wechsler B, Kim H, Gallagher PR, DiScala C, Stineman MG

doi: 10.1038/srep40815 (2017)

Impaired cortical cholinergic neurotransmission may also contribute to b-amyloid plaque pathology in Alzheimers disease and increased phosphorylation of tau, the major component of neurofibrillary tangles [216]