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FIGURE 2 FIGURE 3 The HPG axis (Figure 2, right panel) is essential for the development and regulation of adult male reproductive functions, including testicular growth, testosterone production, sperm development, secondary sex characteristics, and sexual behavior

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Although CQDs have demonstrated substantial promise in imaging, sensing and drug delivery, advancement beyond preclinical research remains restricted by the scarcity of comprehensive toxicological data and large-scale validation, and addressing these challenges will require close interdisciplinary collaboration across chemistry, materials science, bioengineering, pharmacology, and clinical medicine to establish reliable synthesis methods, robust testing, and safety frameworks aligned with regulatory guidelines [103, 174]

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Intact antibodies and other larger molecules, in contrast, are physically unable to enter the conduits, and they are thought to be transported to the LNs only within migratory DCs after proteolytic degradation