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Notably, even though we included all the literature addressing the effects of ES and nutritional interventions in both males and females, the included studies mostly failed to test whether the efficacy of the nutritional supplementation might be sex-specific

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Idiosyncratic DILI (IDILI) is harder to predict and doesnt depend on the dose
actual plaque size reduction 50.2% versus 35.8% ( p = 0.027)
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