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In human, TMAO is mainly derived from gut, where the gut microbiota converts dietary nutrients into TMA, which is absorbed into the bloodstream through the intestinal mucosa, and then transformed into TMAO by hepatic flavin monooxygenases (FMOs) in the liver (Zeisel and Warrier, 2017

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PLCg1 binds to LAT through its n-terminal SH2 domain and to SLP-76 via its SH3 domain