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In vitro studies reported the loss of 90% cell viability by exposing the HepG2 cells to 100 M of pipermethystine and 65% of cell death using 50 M [62]
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This indicates that different varieties exhibited distinct regulatory modules

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Recombinant GPX3 (rGPX3) has been shown to inhibit the cellular senescence of liver cells in a dose-dependent manner, with genes such as CD44 , Nox4 , IFNG , and SERPERINB2 identified as mediators of the suppressive effects of GPX3 on hepatic senescence [171]
