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Sarlette A, Krampfl K, Grothe C, Dengler R, Petri S

doi: 10.1155/2019/7860650

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"Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk"

Importantly, therapeutic strategies should target not only the source of initiation and/or progression of the disease but also self-amplifying mechanisms that sustain emphysema themselves, namely airspace enlargement, ECM breakdown, and progressive mechanical failure, all of which should hinder the self-perpetuation of tissue damage and stabilize lung architecture

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