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Hence, there is growing support for the use of compounds that target only peripheral opioid receptors, avoiding the central nervous system, which helps to reduce the risk of common opioid-related side effects

63, e0026319

The quality of the evidence was further evaluated using an adapted Grading of Recommendations Assessment, Development, and Evaluation (GRADE) model (Additional file 4) [23]

Alpha-lipoic acid, vitamin C, and vitamin E are added to enhance its bioavailability

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