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doi: 10.1056/NEJMoa1212722
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52 Moreover, biomarkers of oxidative stress including plasma 8-hydoxydeoxyguanosine, 8-isoprostane, and erythrocyte protein-bound glutathione, were maintained at low levels in animals fed 80% MR diet for 6 months
Furthermore, chronic activation of microglia releases superoxide through NADPH oxidase and triggers TLR4dependent inflammatory cascades, which reinforce ROS accumulation and neurotoxicity [58]
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