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Cell Biochem 89 , 254261 (2003)

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iPSC-derived astrocytes with GBA1 mutations display astrogliosis, impaired lysosomal cathepsin activity, and -syn aggregation [215] , aligning with observations of autophagic defects (reduced LC3-I and LC3-II fragmentation) in GBA-deficient mice and primary cells [216,217]

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Simultaneously, structural remodeling occurs as impaired mitophagy and heightened apoptosis lead to atrial fibrosis and dilation

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Ferroptosis enhanced diabetic renal tubular injury via HIF-1/HO-1 pathway in db/db mice

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HIGHLY ACTIVE ANTIRETROVIRAL THERAPY (HAART) FOR HIV INFECTION (MITOCHONDRIAL TOXIC, IDIOSYNCRATIC, STEATOSIS

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doi: 10.3389/fnins.2022.874750 [DOI] [PMC free article] [PubMed] [Google Scholar] 47

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