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Hepatocellular granularity may be due to swelling of cell organelles or increase in the numbers of cell organelles including peroxisomes, mitochondria, and smooth endoplasmic reticulum

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It is synthesised from the isomerisation of 1,3-bisphosphoglycerate, as a phosphoryl group is transferred from C1 to C2 and catalysed by bisphosphoglycerate mutase

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Standard dosing for skin benefits typically ranges from 250 mg to 500 mg per day, and oral supplements are generally well-tolerated with minimal side effects

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