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Compound (NP7) is an anti-oxidant and could cross The BBB

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Nature 533 , 481486 (2016)

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Nature 520 , 553557 (2015)

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The THP in HCl solution (pH 2.0 or 4.0) was mixed with pepsin to give pepsin-to-protein weight ratio of 1:30

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Biochemically, this phase is associated with reduced activity of HIF- and upregulation of Sirtuin activity

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10.1016/j.bbamcr.2018.02.010 Biochim Biophys Acta Mol Cell Res

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