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Additionally, one study of over 400 human subjects found different regression profiles for selenium and GPx-1 activity for each genotype: the correlation of GPx-1 activity with plasma selenium concentrations was higher for the Pro/Pro genotype than the Leu/Leu genotype, providing evidence that GPx-1 genotypes can modulate the expression of GPx-1 in response to selenium in vivo (183)

[DOI] [PubMed] [Google Scholar] 17.Kima J.H., Naa J.H., Kima C.K., Kima J.Y., Haa K.S., Leeb H., Chungc H.T., Kwond H.J., Kwone Y.G., Kim Y.M
doi: 10.1111/J.0954-6820.1978.TB08402.X

doi: 10.1186/s12967-023-04802-3

B6 accumulation and upper limits While vitamin B6 is water-soluble and excess amounts are excreted through urine, chronic high-dose supplementation can cause problems

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