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In milder cases, deficiency may present as persistent fatigue, irritability, poor concentration, and digestive discomfort

Substantial variability emerged among individual agents: exenatide demonstrated the longest median latency (54 days, IQR 16184), while dulaglutide showed the shortest (7 days, IQR 234)

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It functions as a primary downstream mediator of growth hormone activity and is extensively researched for its involvement in cellular proliferation, differentiation, and anabolic signalling mechanisms