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Given that fibrotic plaque is similar to mechanical abnormal structure, the appropriate micro-trauma by the injection may be beneficial to plaque remodeling and treatment similar to operative resection ( Verapamil As a calcium channel blocker used in the treatment of hypertension, verapamil plays an anti-fibrotic role by blocking the transportation of calcium into fibroblasts, inhibiting the transfer of proline into the matrix and stimulating the phenotype transformation of fibroblasts to produce collagenase ( Interferon-2b Interferon is a kind of low molecular weight protein characterized by modulating immune function in anti-proliferative or anti-neoplasm effects ( in vitro IFN2b could decrease fibroblasts proliferation, reduce the collagen synthesis and deposition, and increase collagenase activity in fibrotic plaques ( Corticosteroids Intralesional corticosteroids were used in the treatment of PD because of its property of inhibiting inflammation

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R.et al (2021)

Marked improvement should be seen within six to eight weeks of starting the maintenance dose, with a full reversal of clinical signs after four to six months of treatment