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Il GHK ha un'elevata affinit per gli ioni rame, e il complesso GHK-Cu svolge il ruolo di trasportatore del rame verso le cellule

doi: 10.1016/j.cell.2010.06.028 35 MaLChenCZhaoCLiTMaLJiangJet al

Other contributing factors include nutritional deficiencies, skin injuries, and underlying medical conditions, all of which can lead to hyperpigmentation in this area

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In line with this possibility, it has been shown that GSH protects against APAP-induced hepatotoxicity and liver injury in mice through the scavenging of ONOO - ( FIGURE 2 Role of JNK As mentioned, NAPQI generation can directly cause oxidative stress and mitochondrial dysfunction following mitochondrial protein adduct formation

The specific metabolites that differed within enriched pathways mentioned above are listed in supplemental table 4