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associated with B12 deficiency with long-term use (per ADA 2026, monitor B12 periodically) SGLT-2 inhibitors (empagliflozin, dapagliflozin, canagliflozin): Glucosuria mechanism

Statin bioavailability may be slightly reduced due to delayed gastric transit, but this effect is typically minor and does not require dose adjustment

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Commonly used : Less frequently than norethisterone but still prescribed in certain cases