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109 used a brush functionalization technique to create a gradient of TGF-3, decreasing in concentration from the articulating surface to the subchondral region, and likewise created a reverse gradient of BMP-2

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10.1111/j.1365-2990.2005.00656.x 56 CrossA

VEGF upregulation drives neovascularisation, the formation of new blood vessels from pre-existing vasculature

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