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NPs enter the systemic circulation through clathrin- and caveolae-mediated endocytosis in the intestinal lymphatic region, specifically accumulating in the arthritis joint and reducing the progression of the disease ( Manipulation of Macrophages by Nanomaterials for the Diagnosis of RA In patients with RA, the pathological damage to the structure of the joint cannot be reversed
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Quercetin reduces illness but not immune perturbations after intensive exercise
PMID: 25208511
10.1038/s41598-021-00957-5
