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A number of mutations have been identified (Mayatepek et al., 2000)

Badmaev, V., Majeed, M., & Prakash, L
Real-world clopidogrel utilization in acute coronary syndromes: patients selection and outcomes in a single-center experience

Mansouri, A
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We postulate that the ionization of the lipid caused lower retention of the RNA, which then resulted in lower transfection and in vivo delivery efficiencies, as confirmed by the failure to induce an antibody response against HIV-1 Env gp140