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This is what is observed with specific constituents of MLE such as quercetin, rutin, gallic acid, caffeic acid and rosmarinic acid

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[DOI] [PubMed] [Google Scholar] 26.Decramer M., Rutten-van Mlken M., Dekhuijzen P.N., Troosters T., van Herwaarden C., Pellegrino R., van Schayck C.P., Olivieri D., Del Donno M., De Backer W., Lankhorst I., Ardia A

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Current limitations include the lack of early-phase clinical trials and safety concerns in cirrhotic livers, the lack of specificity and systemic toxicity of available NRF2 inhibitors, the genetic and molecular heterogeneity in HCC tumors, and the absence of validated biomarkers for NRF2 activity and therapeutic response
