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Research has demonstrated that augmented glutamine metabolism in CAFs gives rise to collagen-rich extracellular matrix and fosters tumor development [134, 135]
The early identification of AD with conventional biomarkersthe ATN framework: A is amyloid, T is phosphorylated tau, and N is neurodegenerationis problematic because they may overlap with the natural aging process

10.1515/REVNEURO.2008.19.4-5.341 [DOI] [PMC free article] [PubMed] [Google Scholar] Eagleson K

Neuropharmacology 33: 635640

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These data indicate that decreased barrier integrity is a pathophysiological phenotype of FA brain microvascular endothelial cells