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Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

10.1016/j.tibs.2015.11.012 [DOI] [PMC free article] [PubMed] [Google Scholar] Borgna-Pignatti C., Solinas A., Bombieri C., Micciolo R., Gamberini M

Current gene therapy research aims to target, for example, upstream targets of the GSH system or molecules associated with it (such as Nrf2, GPX, SLC7A11), genes aberrantly expressed in myocardial injury, and noncoding RNAs regulating mRNA transcription [76, 202, 250253]

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Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model