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They do so primarily through the release of the T H 1 cytokine interferon-

The gut microbiome directly influences dopamine, GABA, and other neurotransmitter production

SOD1-mutant mice exhibited mitochondrial ultrastructural pathologies in spinal cord and skeletal muscle tissues, manifesting as reduced mitochondrial length, cristae disorganization, and increased spherical fragmented mitochondria (Mendez-Lopez et al., 2021)

A neurological severity score (NSS), has been utilized to assess for motor and cognitive deficits post-injury (Shapira et al., 1993)

doi: 10.1016/0006-2952(76)90004-6

The animal results were promising