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Arginine HCl Injection works by providing a large amount of arginine into the bloodstream, which triggers physiological responses

Nasal route of Vitamin B12 administration is easy.

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Oral supplements were convenient but useless

doi: 10.1016/j.freeradbiomed.2018.12.011 21 SabatierMBirsenRLautureLMoucheSAngelinoPDehairsJet al

In addition, small molecule inhibitors including SLC7A11 inhibitor HG106 and GCLC inhibitor buthionine sulfoximine (BSO) were introduced to investigate their effects on ROS, GSH levels and cellular viability in VRK2-KO and VRK2-KD cells, and the results were consistent with the above knockdown experiment (Fig