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Description
Since serine feeds into one-carbon metabolism supporting nucleotide synthesis, methylation reactions, and redox homeostasis, blocking serine synthesis can have pleiotropic anti-tumor effects

Early small trials (some unblinded) of glycine and D-serine were encouraging [93,94,95,96,97,98]

Richard Frye, and we will look at how to translate the Persico 2025 systematic review into a sequenced clinical strategy for the families and practitioners who walk this road every day
Synthesize DNA and RNA

Jain P, Kantarjian HM, Luthra R, Gonzalez GN, Jabbour E, Sasaki K, Guillermo Romo C, Patel KP, Kadia T, Borthakur G , Estrov Z, Ravandi F, O'Brien S, Cortes JE

Nutrients 2019, 11 (8), 1894
