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5: 116 Ferrari R, Ceconi C, Cargnoni A, et al

SERPINE1 rs6092 variant is related to plasma coagulation proteins in patients with severe COVID-19 from a tertiary care hospital

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Consistent data show that the inflammatory process can be triggered by protein misfolding or protein accumulation, which are the initial events of a given pathology (i.e., amyloid for AD, tau protein for frontal dementia, alpha synuclein for PD, etc