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Background Emerging ferroptosis-driven therapies based on nanotechnology function either by increasing intracellular iron level or suppressing glutathione peroxidase 4 (GPX4) activity

The cystine/glutamate antiporter System xc- exports glutamate to the extracellular space and is therefore implicated as driving excitotoxicity

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The metabolism of sugars, fats, and amino acids in cancer cells is altered to fuel their unlimited growth, and these alterations are often brought about by epigenetic changes, such as changes in the three-dimensional structure of DNA