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Ferroptosis is a widely acknowledged and seemingly intuitive method of cell death in FXN deficiency, and could be responsible for neuronal death

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Among all parameters tested, we observed that CCR2 expression ( Figure 7B ), FLICA + ASC-speck monocyte frequency ( Figure 7D ), caspase-1 activity ( Figure 7E ), lipid peroxidation ( Figure 7F ), intracellular GSH levels ( Figure 7H ) and spontaneous cytokine release in vitro were all significantly altered in the COVID-19 recovered group versus HCs, indicating that short-term recovery does not afford a return to previous levels for these measurements ( Figure 7 )

No changes in body weight or food consumption were detected among treatments (Extended Data Fig