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These markers correlate directly with pineal gland melatonin output and indicate whether circadian-targeted therapy is physiologically indicated

Psychological Impact of Poor Response Experiencing little or no improvement despite starting therapy can have emotional consequences as well

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J Exp Bot 65:527538 Belkadhi A, Hediji H, Abbes Z, Djebali W, Chabi W, (2012) Influence of salicylic acid pre-treatment on cadmium tolerance and its relationship with non-protein thiol production in flax root