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Supports the immune system Vitamin B12 and folate play roles in cellular proliferation and differentiation, making them essential for a properly functioning immune system that helps the body fight infection and illnesses

The limitation of that study was the small number of patients, but the authors concluded that compared with healthy neonates, the HIE group had increased melatonin, SOD, and NO concentrations, and the combination of melatonin to therapeutic hypothermia in infants with HIE can improve neurodevelopmental outcome at 6 months of age with effective effects in reducing oxidative stress in terms of NO and SOD serum level reduction

However, clinical trials in humans have demonstrated mixed results

Evidence summarized in a clinical review on nutraceutical management of concussion suggests curcumin may help mitigate secondary injury cascades that follow concussion (source)

Efficacy of adoptive therapy with tumor-infiltrating lymphocytes and recombinant interleukin-2 in advanced cutaneous melanoma: a systematic review and meta-analysis