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Gut microbiota have been shown to play an important role in brain function through the gutbrain axis [211,212,213]

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Notably, the phosphorylation levels of the downstream targets 4E-BP1 and S6K1 and the highly related but functionally distinct kinases Akt and SGK1 were substantially reduced following mTOR inhibition, which was in agreement with a decrease in cell apoptosis

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