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As the surface characteristics are primarily responsible for the toxicity of the NPs, modification of surface chemistry and properties has been reported to be one of the most common devised strategies to mitigate NP toxicity (Figure 3) ( FIGURE 3 Surface coating is one of the most popular surface modification strategies to reduce the potential toxicity of NPs, which is reversible by non-covalent modification (Hwang et al., 2018)

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It occurs naturally in human plasma and was first isolated in 1973 by Loren Pickart

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Thereby, methodologically, the harmful effect of retrobulbar L-NAME application and the therapeutic effect of BPC 157 can both be direct effects with long-term consequences [13]