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Oral mucosal melanin hyperpigmentation may be secondary to disease, medications, or smoking, and physiological oral melanin hyperpigmentation may be clinically and histopathologically similar so that the differentiation between pathological and physiological oral melanosis can at times be difficult

All combinations result in sustained virological response rates above 95% in this patient population and are generally very well tolerated

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doi: 10.1007/s00253-021-11582-7 7 WangHRongXZhaoGZhouYXiaoYMaDet al

Solar lentigines may appear similar to pigmented actinic keratoses (adherent scale and tenderness) or flat seborrhoeic keratoses (dry surface)

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