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Apart from systemic circulation, BBB crossing is also crucial for drug delivery to the brain

(PubMed) Brady JF, Ishizaki H, Fukuto JM, et al

In contrast to most terminally differentiated somatic cells, adult stem cells undergo extensive proliferation and differentiation processes, increasing the likelihood of DNA damage during DNA replication

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Copper acts as a cofactor in various enzymes and performs essential roles in photosynthesis, respiration and the electron transport chain, and is a structural component of defense genes