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However, this totally changes for middle-aged and older people

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[DOI] [PubMed] [Google Scholar] 140.Shimbashi W, Sugitani I, Kawabata K, Mitani H, Toda K, et al

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This considerable variability in stimulation parameters makes it difficult to reproduce and compare results between studies (Olsen et al

Concurrently, children exhibit immature adaptive immune development, making them more susceptible to Th2 response skewing (elevated IL-4/IFN- ratio) in CD4+ T cell responses, Tregs function remains relatively underdeveloped, and B cells and follicular helper T cells demonstrate delayed or inadequate antibody production, thereby weakening immune clearance efficiency and promoting immunopathological damage (50)