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diarrhea is typically secondary to conditions causing malabsorption (e.g., IBD, celiac) rather than B12 itself

To address these challenges, various delivery methods have been investigated, including viral vectors, non-viral vectors, and rational design strategies such as chemical modifications, cationic liposomes, polymers, nanocarriers, and biocoupled siRNAs, aimed at enhancing stability and intracellular delivery (Liu F

This provides an important tool for research into aging-related neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, and offers experimental evidence for intervention strategies in neuronal aging

It varies based on individual factors, such as the cause and severity of the deficiency