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Absorption and Bioavailability Direct Delivery Vitamin B12 injections provide a direct delivery method, bypassing the digestive system
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Standard Handling Considerations Reconstitution practice When reconstituting, the diluent is typically added slowly down the inside wall of the vial rather than directly onto the lyophilized powder, and the vial is swirled gently rather than shaken

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Commonly reported issues include mild gastrointestinal discomfort, particularly when starting the compound, and temporary headaches during the adjustment period

doi: 10.1182/blood-2007-07-101600 16 ZilberM-TSetterbladNVasselonTDoligerCCharronDMooneyNet al
