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Abbreviations ICH: Intracerebral hemorrhage EVs: Extracellular vesicles Hypo-Exos: ROS-responsive three-dimensional (3D) biological scaffold encapsulating hypoxia-primed EVs PBA: Phenylboronic acid PVA: Polyvinyl alcohol HIF-1: Hypoxia-inducible factor-1 M1: Microglia rapidly polarize into pro-inflammatory M2: Microglia rapidly polarize into anti-inflammatory hUCMSCs: Human umbilical cord mesenchymal stem cells 3D biological scaffold: Three-dimensional (3D) biological scaffold 3D biological scaffold @exos: Hypo-Exos were encapsulated within this scaffold ESR: Electron spin resonance GFAP: Glial fibrillary acidic protein dECM: Decellularized brain matrix ROS: Reactive oxygen species ECM: Extracellular matrix NC: Nervous cell H&E: Hematoxylin and eosin SEM: Scanning electron microscopy FT-IR: Fourier-transform infrared CCK8: Cell Counting Kit-8 FPT: The Forelimb Placing Test CTT: Corner turn test TEM: Transmission electron microscopy FJC: Fluoro-Jade C MDA: Malondialdehyde GSH: Glutathione GelMA: Gelatin methacrylate References Zhang A, Cong L, Nan C, Zhao Z, Liu L

111 Nuclear localization of NOX1 and its RAC1-mediated activation to generate ROS have been implicated in the degeneration of nigrostriatal dopaminergic neurons in animal models of PD