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Specifically, a high-fat and high-sugar diet increased the -amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid to N-methyl-D-aspartic acid receptor current ratio in medium spiny neurons and prolonged spontaneous glutamate-mediated currents, increased DA release and slower DA reuptake in the striatum, and reduced MOR-mediated synaptic plasticity (73)

Front Genet 2022;13:875694

If you experience this and do not wish to continue with glutathione, there are other methods to increasing your glutathione naturally without supplementing with it

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Neutrophil extracellular traps (NETs) are a major source of guanylated autoantibodies